-
factors for EPO,
known as hypoxia-inducible factors, are
hydroxylated and
proteosomally digested in the
presence of
oxygen and iron.
During normoxia GATA2 inhibits...
-
attach a
chain of
ubiquitin molecules to p53,
thereby flagging p53 for
proteosomal degradation. Normally, p53 acts to
prevent cell
growth and
promotes cell...
-
inhibition of hypoxia-inducible
factor 1 α (HIF-1α) by
ubiquitin mediated proteosomal degradation. In
these dysfunctional cells pVHL
cannot degrade HIF-1α...
-
cellular level of β-catenin is
mostly controlled by its
ubiquitination and
proteosomal degradation. The E3
ubiquitin ligase TrCP1 (also
known as β-TrCP) can...
- however, is that Co2+
binding permits Ubiquitin binding but
prevents proteosomal degradation. In 2004, a test for
detection allogeneic/homologous blood...
- of TGF β signaling, GIPC,
binds to its PDZ domain,
which prevents its
proteosomal degradation,
which subsequently increases TGFβ activity. It may also...
-
Deubiquitination removing ubiquitin from D2
restores its
activity and
prevents proteosomal degradation. The
Hedgehog cascade acts to
increase D2 ubiquitination...
-
undergoes apoptosis in
early development. CTDNEP1
helps promote Ubiquitin by
proteosomal degradation. CTDNEP1 mRNA is
derived from
maternal genes and is localized...
- of cell
lines growth and survival. The
inhibition of Hsp90
causes the
proteosomal destruction of
client proteins- Akt, KIT and IGF1R. This
effect could...
-
involved in
regulation of Akt
signaling by
targeting phosphorylated Akt to
proteosomal degradation.
Proposed to
preferentially act as a SUMO E3
ligase at physiological...
