-
attach a
chain of
ubiquitin molecules to p53,
thereby flagging p53 for
proteosomal degradation. Normally, p53 acts to
prevent cell
growth and
promotes cell...
- of TGF β signaling, GIPC,
binds to its PDZ domain,
which prevents its
proteosomal degradation,
which subsequently increases TGFβ activity. It may also...
- the gene (exon 34).
These mutations remove PEST domains,
which mediate proteosomal destruction of the protein.
These PEST
domains are
removed due to the...
-
factors for EPO,
known as hypoxia-inducible factors, are
hydroxylated and
proteosomally digested in the
presence of
oxygen and iron.
During normoxia GATA2 inhibits...
-
inhibition of hypoxia-inducible
factor 1 α (HIF-1α) by
ubiquitin mediated proteosomal degradation. In
these dysfunctional cells pVHL
cannot degrade HIF-1α...
- however, is that Co2+
binding permits Ubiquitin binding but
prevents proteosomal degradation. In 2004, a test for
detection allogeneic/homologous blood...
-
cellular level of β-catenin is
mostly controlled by its
ubiquitination and
proteosomal degradation. The E3
ubiquitin ligase TrCP1 (also
known as β-TrCP) can...
-
containing GSK3 (glycogen
synthase kinase 3)
which targets β-Cat for
proteosomal degradation. In the nucleus,
members of the T-cell
factor (TCF) family...
-
degradation by proteasomes. "Hakai"
means "destruction" in ****anese.
Proteosomal degradation of E-cadherin can be
regulated by phosphorylation. The Hakai...
- of cell
lines growth and survival. The
inhibition of Hsp90
causes the
proteosomal destruction of
client proteins- Akt, KIT and IGF1R. This
effect could...
