- A
protein precursor, also
called a pro-protein or pro-peptide, is an
inactive protein (or peptide) that can be
turned into an
active form by post-translational...
-
synthesised with
signal and
propeptides. The
animal pepsin-like
endopeptidase propeptides form a
distinct family of
propeptides,
which contain a conserved...
- (zymogens) with N-terminal
propeptide regions. The
activation process of
these enzymes includes the
removal of
propeptide regions,
which serve a variety...
- post-translational
modification consist of
cleaving peptide bonds, as in
processing a
propeptide to a
mature form or
removing the
initiator methionine residue. The formation...
-
prepropeptide includes a 22-amino acid
signal peptide (SP), a 741-amino acid
propeptide (VWFpp), and a 2050-amino acid
mature VWF monomer. The
signal peptide...
-
attached to the C-terminus
after proteolytic cleavage of a C-terminal
propeptide. The most
prominent example for this type of
modification is the prion...
-
extracellular matrix. In
humans the MMP9 gene
encodes for a
signal peptide, a
propeptide, a
catalytic domain with
inserted three repeats of
fibronectin type II...
- of the enzyme.
Several such
propeptides share a
similar topology,
despite often low
sequence identities. The
propeptide region has an open-sandwich...
- two halves: a
unique N-terminal
propeptide domain and a C-terminal
BRICHOS domain. The
around 100-aa long
propeptide domain actually contains not only...
-
sequence is
removed in the
endoplasmic reticulum,
yielding a
propeptide. The
propeptide travels to the
Golgi apparatus where it is
proteolytically cleaved...
