- humans,
proinsulin is
encoded by the INS gene. The
pancreatic islets only
secrete between 1% and 3% of
proinsulin intact. However,
because proinsulin has...
-
where its
signal peptide is
removed by
signal peptidase to form
proinsulin. As the
proinsulin folds,
opposite ends of the protein,
called the "A-chain" and...
- 31-amino-acid
polypeptide that
connects insulin's A-chain to its B-chain in the
proinsulin molecule. In the
context of
diabetes or hypoglycemia, a
measurement of...
- more
peptide hormones.
Examples of natural,
human prohormones include proinsulin and pro-opiomelanocortin, but the most
widespread prohormones in use are...
- As
glucose stimulates insulin secretion, it
simultaneously increases proinsulin biosynthesis through translational control and
enhanced gene transcription...
-
usually made
biochemically with low
blood glucose,
elevated insulin,
proinsulin, and C-peptide levels, and
confirmed by
localizing the
tumour with medical...
- the
precursor for a
protein is
often prefixed by pro-.
Examples include proinsulin and proopiomelanocortin,
which are both prohormones.
Protein precursors...
-
Insulin and
Human Proinsulin, U.S.
Patent No. 4,652,547,
issued March 24, 1987 RE Chance, BH Frank, JA Galloway,
Human Proinsulin Pharmaceutical Formulations...
-
through blood work
revealing high
insulin levels with low C-peptide and
proinsulin. The
production of
glucose is
blocked by alcohol. In
those who misuse...
-
mutations Genetic defects in
insulin processing or
insulin action Defects in
proinsulin conversion Insulin gene
mutations Insulin receptor mutations Exocrine...
