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Caspases (cysteine-aspartic proteases,
cysteine aspartases or cysteine-dependent aspartate-directed proteases) are a
family of
protease enzymes playing...
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inhibits the
close interaction of the
procaspases to one another.
Without this
close proximity, the
procaspases cannot be
completely cleaved and remain...
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present as zymogens,
termed procaspases,
which are
inactive until a
biochemical change causes their activation. Each
procaspase has an N-terminal
large subunit...
- of
cellular signalling pathways. The DED
domain is
found in
inactive procaspases (cysteine proteases) and
proteins that
regulate caspase activation in...
- prothrombin, or plasminogen) Some of the
proteins of the
complement system Procaspases Pacifastin Proelastase Prolipase Procarboxypolypeptidases Enzyme Protein...
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apoptosis signalling molecules simultaneously bind
multiple procaspases. The
procaspases transactivate via cleavage,
activate additional caspases in the...
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death domain (FADD)
translocates with the DISC,
allowing recruitment of
procaspases 8 and 10.
These caspases then
activate the
effector caspases 3, 6, and...
-
Gandhi V (February 2015). "Expression of
executioner procaspases and
their activation by a
procaspase-activating
compound in
chronic lymphocytic leukemia...
- the
ground state apoptosome. Once
apoptosome binds to
procaspase-9, the Apaf-1
CARDs and
procaspase-9
CARDs form a
flexible disk-like
structure sitting...
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proteins and
procaspase-8 (composed of FLICE, MACH, and Mch5) bind to CD95
through death domain and
death effector domain interactions.
Procaspase-8 activation...
