-
Caspases (cysteine-aspartic proteases,
cysteine aspartases or cysteine-dependent aspartate-directed proteases) are a
family of
protease enzymes playing...
- prothrombin, or plasminogen) Some of the
proteins of the
complement system Procaspases Pacifastin Proelastase Prolipase Procarboxypolypeptidases Enzyme Protein...
-
apoptosis signalling molecules simultaneously bind
multiple procaspases. The
procaspases transactivate via cleavage,
activate additional caspases in the...
-
death domain (FADD)
translocates with the DISC,
allowing recruitment of
procaspases 8 and 10.
These caspases then
activate the
effector caspases 3, 6, and...
-
inhibits the
close interaction of the
procaspases to one another.
Without this
close proximity, the
procaspases cannot be
completely cleaved and remain...
- mitochondria.
Releasing of
cytochrome c from the IMS to the
cytosol activates procaspases and
triggers a
caspase cascade leading to apoptosis. The intermembrane...
-
apoptosis signalling molecules simultaneously bind
multiple procaspases. The
procaspases transactivate via cleavage,
activate additional caspases in the...
-
signal be received. In parallel,
these enzymes activate proapoptotic procaspase-8,
which does
directly activate the
mitochondrial events of apoptosis...
-
present as zymogens,
termed procaspases,
which are
inactive until a
biochemical change causes their activation. Each
procaspase has an N-terminal
large subunit...
-
blocking the
recruitment of
procaspase-9 to the Apaf-1/dATP/cytochrome c
apoptosome complex. It does not bind
directly to the
procaspase-9
binding site, but likely...
