-
balance is the
proportion of
proapoptotic homodimers that form in the outer-membrane of the mitochondrion. The
proapoptotic homodimers are
required to make...
- of the most
studied roles of
ceramide pertains to its
function as a
proapoptotic molecule. Apoptosis, or Type I
programmed cell death, is
essential for...
- (Bcl-2-related
ovarian death gene) is an
ovarian BH3 domain-containing
proapoptotic Bcl-2
protein capable of
dimerization with
diverse antiapoptotic Bcl-2...
-
proteins (IAPs), thus
freeing caspases to
activate apoptosis. Due to its
proapoptotic function, SMAC is
implicated in a
broad spectrum of tumors, and small...
- activation, may
increase the
chemosensitivity of many cancers: an
example of
proapoptotic signal modulation therapy".
Integrative Cancer Therapies. 5 (3): 252–68...
- (Bcl-2-related
ovarian death gene) is an
ovarian BH3 domain-containing
proapoptotic Bcl-2
protein capable of
dimerization with
diverse antiapoptotic Bcl-2...
-
fragment cleaved from
collagen that
serves as both an
antiangiogenic and
proapoptotic agent. It has
similar function to canstatin, endostatin, restin, and...
-
peptidomimetic with
sequence CKGGRAKDC-GG-D(KLAKLAK)2. It is an
experimental proapoptotic drug that has been
shown to
cause rapid weight loss in mice and rhesus...
- to
enhance acetylation and
subsequent transcription. GAPDH's
targets proapoptotic genes such as p53, p53
upregulated modulator of
apoptosis (PUMA), and...
-
downregulation of the anti-apoptotic
protein Bcl-2 and
upregulation of the
proapoptotic protein Bax.
These connections suggest a role of caspase-dependent apoptosis...
