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Pretomanid is an
antibiotic medication used for the
treatment of multi-drug-resistant
tuberculosis affecting the lungs. It is
generally used
together with...
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variety include metronidazole, tinidazole, nimorazole, dimetridazole,
pretomanid, ornidazole, megazol, and azanidazole.
Drugs based on 2-nitroimidazoles...
- PA-824 (now
pretomanid), OPC-67683 (now delamanid), and R207910 (now bedaquiline), all of
which are in
Phase II of development.
Pretomanid and delamanid...
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August 2019, the Food and Drug
Administration (FDA)
approved the use of
pretomanid in
combination with
bedaquiline and
linezolid for
treating a
limited and...
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shown to be
important in the
action of
another antimycobacterial prodrug pretomanid.
Isoniazid is
bactericidal to
rapidly dividing mycobacteria, but is bacteriostatic...
- (TB)
medicine pretomanid was
accepted for
review by the U.S. FDA. In
August 2019, TB Alliance's
tuberculosis (TB)
medicine pretomanid was
approved by...
- to
which mycolic acid
would be attached. This
mechanism is
shared with
pretomanid.
Clinical isolates resistant to this drug tend to have
mutations in the...
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Morinamide J04AK05
Bedaquiline J04AK06
Delamanid J04AK07
Amithiozone J04AK08
Pretomanid J04AM01
Streptomycin and
isoniazid J04AM02
Rifampicin and
isoniazid J04AM03...
-
highly reactive and
attacks cell wall
synthesis enzymes such as DprE2.
Pretomanid works in the same way.
Clinical isolates resistant to
these two drugs...
-
trial or on a comp****ionate basis.
Their efficacy and
safety are unknown:
Pretomanid (manufactured by Novartis,
developed in
partnership with TB Alliance)...
