- The
first p****
effect (also
known as first-p****
metabolism or
presystemic metabolism) is a
phenomenon of drug
metabolism at a
specific location in the...
-
administration (as
succinate salt) has low bioavailability,
partly due to
presystemic metabolism—some of it gets
broken down in the
stomach and bloodstream...
- ISBN 978-3-642-60107-1.
Aungst BJ, Matz N (26
August 2007). "Prodrugs to
Reduce Presystemic Metabolism". In
Stella V,
Borchardt R,
Hageman M,
Oliyai R, Maag H, Tilley...
- 1982;22(2):175-9. Pond SM, Tong T,
Benowitz NL,
Jacob P,
Rigod J (August 1981). "
Presystemic metabolism of
meperidine to
normeperidine in
normal and
cirrhotic subjects"...
- doi:10.1002/chir.20397. PMID 17393472.
Berry BW,
Jamali F (1991). "
Presystemic and
systemic chiral inversion of R-(-)-fenoprofen in the rat". The Journal...
-
Morales RJ, De Witt KE,
Rajewski G, et al. (October 1996). "Absorption and
presystemic metabolism of
selegiline hydrochloride at
different regions in the gastrointestinal...
- ISBN 978-3-642-60107-1.
Aungst BJ, Matz N (26
August 2007). "Prodrugs to
Reduce Presystemic Metabolism". In
Stella V,
Borchardt R,
Hageman M,
Oliyai R, Maag H, Tilley...
- ISBN 978-3-642-60107-1.
Aungst BJ, Matz N (2007). "Prodrugs to
Reduce Presystemic Metabolism". Prodrugs. Biotechnology:
Pharmaceutical Aspects. Vol. V...
