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Presenilins are a
family of
related multi-p****
transmembrane proteins which constitute the
catalytic subunits of the gamma-secretase
intramembrane protease...
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Presenilin-1 (PS-1) is a
presenilin protein that in
humans is
encoded by the PSEN1 gene.
Presenilin-1 is one of the four core
proteins in the
gamma secretase...
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Presenilin-2 is a
protein that (in humans) is
encoded by the PSEN2 gene. Alzheimer's
disease (AD)
patients with an
inherited form of the
disease carry...
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mutation in one of at
least three genes,
which code for
presenilin 1,
presenilin 2, and APP. The
presenilin 1 gene (PSEN1
located on
chromosome 14) was identified...
- four
individual proteins: PSEN1 (
presenilin-1), nicastrin, APH-1 (anterior pharynx-defective 1), and PEN-2 (
presenilin enhancer 2).
Recent evidence suggests...
- Alzheimer's
disease has been
strongly linked to
mutations in the
presenilin 1 (PS1),
presenilin 2 (PS2), and
amyloid precursor protein (APP) genes. All of the...
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protein 3 (Dock3), also
known as MOCA (modifier of cell adhesion) and PBP (
presenilin-binding protein), is a
large (~180 kDa)
protein encoded in the
human by...
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cells overexpressing mutant human Presenilin 1, and in
brain tissue in
knockin mice that
express mutant Presenilin 1 at
normal levels, and thus may play...
- PSENEN,
formally PEN-2 (
presenilin enhancer 2), is a
protein that is a
regulatory component of the
gamma secretase complex, a
protease complex responsible...
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components of the
gamma secretase complex along with the
catalytic subunit presenilin and the
regulatory subunits nicastrin and PEN-2. The gamma-secretase complex...
