-
inactive precursor molecule, a 110
amino acid-long
protein called preproinsulin.
Preproinsulin is
translated directly into the
rough endoplasmic reticulum (RER)...
-
peptide is
cleaved off in the
endoplasmic reticulum. An
example is
preproinsulin. Pro-sequences are
areas in the
protein that are
essential for its correct...
-
similar clinical features. In the
insulin synthesis pathway,
first preproinsulin is
translocated into the
endoplasmic reticulum of beta
cells of the...
-
Retrieved on 2011-06-28. Chan, Shu Jin; et al. (1984). "Guinea pig
preproinsulin gene: an
evolutionary compromise?".
Proceedings of the
National Academy...
- carbohydrates.
Insulin is
initially created as a
precursor form
called preproinsulin. This is
converted to
proinsulin and
cleaved by C-peptide to insulin...
-
first transcribed into mRNA and
translated into
preproinsulin.
After translation, the
preproinsulin precursor contains an N-terminal
signal peptide that...
- the AUG
initiator codon affect the
efficiency of
translation of rat
preproinsulin in vivo". Nature. 308 (5956): 241–246. Bibcode:1984Natur.308..241K....
-
their final active structures. Insulin, for example, is
synthesized as
preproinsulin,
which yields proinsulin after the
signal peptide has been cleaved....
-
change mutations found in the B
domain lead to the disease.
insulin preproinsulin signal peptide signal peptide peptidase proprotein convertase 1 (PC1)...
-
convert itself to an
active hormone. Some pro-protein precursors, such as
preproinsulin, also go
through this process, with the
added step of
removing a signal...
