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Prelamin-A/C, or
lamin A/C is a
protein that in
humans is
encoded by the LMNA gene.
Lamin A/C
belongs to the
lamin family of proteins. In the
setting of...
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structural protein called prelamin A,
which undergoes a
series of
processing steps before attaining its
final form,
called lamin A.
Prelamin A
contains a "CAAX"...
- a
precursor form
called prelamin A.
Prelamin A and
lamin C
differ in
structure only at the carboxyl-terminus. Here,
prelamin A
contains two
extra exons...
-
mutation in the
processed prelamin A
messenger RNA,
causing the
deletion of a 50 amino-acid
group near the C-terminus of the
prelamin A protein. The endopeptidase...
- protein. This
version of the
protein is also
referred to as
prelamin A.
Farnesylated prelamin A is
further processed into
mature lamin A by a metalloproteinase...
-
farnesylated prelamin A into
mature non-farnesylated lamin, or by a
mutation in the LMNA gene. This
results in the ac****ulation of farnesyl-
prelamin A at the...
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Nuclear prelamin A
recognition factor, also
known as NARF, is a
protein which in
humans is
encoded by the NARF gene.
Several proteins have been
found to...
- precursor, this
cleavage is not
possible and the
prelamin A
cannot mature. When the
truncated prelamin A is
localized to the
nuclear envelope, it will...
-
Nuclear prelamin A
recognition factor like is a
protein that in
humans is
encoded by the
NARFL gene. GRCh38:
Ensembl release 89: ENSG00000103245 – Ensembl...
-
abolishing the ZMPSTE24
cleavage site in
prelamin A
causes a
progeroid disorder.
Failure to
correctly process prelamin A
leads to
deficient ability to repair...
