Definition of Prekallikrein. Meaning of Prekallikrein. Synonyms of Prekallikrein

- Prekallikrein (PK), also known as Fletcher factor, is an 85,000 Mr serine protease that complexes with high-molecular-weight kininogen. PK is the precursor...
- collagen by high-molecular-weight kininogen (HMWK), prekallikrein, and FXII (Hageman factor). Prekallikrein is converted to kallikrein and FXII becomes FXIIa...
- the KLKB1 gene. This enzyme is formed from prekallikrein (Fletcher factor) by factor XIIa. Plasma prekallikrein is a glycoprotein that parti****tes in the...
- antiangiogenic properties; binding to negatively charged surfaces Domain 6 - prekallikrein and factor XI binding (amino acids 420 to 510)(histidine rich) HMWK...
- activation system or CAS, three proteins in the blood, factor XII (FXII), prekallikrein (PK) and high molecular weight kininogen (HK), bind to a surface and...
- themselves.[citation needed] HMWK is produced by the liver together with prekallikrein (see below). It acts mainly as a cofactor on coagulation and inflammation...
- binds to prekallikrein messenger RNA (mRNA) and degrades it by means of ribonuclease H1, which results in the reduced production of prekallikrein protein...
- bradykinin. The inhibition of FXIIa therefore prevents the activation of prekallikrein into kallikrein and the generation of bradykinin, which is ****ociated...
- and is part of the coagulation cascade. It activates factor XI and prekallikrein in vitro. FXII is activated to FXIIa by negatively charged surfaces...
- inheritance since the gene for factor XI is located on chromosome 4 (near the prekallikrein gene); and it is not completely recessive, individuals who are heterozygous...