-
Prekallikrein (PK), also
known as
Fletcher factor, is an 85,000 Mr
serine protease that
complexes with high-molecular-weight kininogen. PK is the precursor...
- the KLKB1 gene. This
enzyme is
formed from
prekallikrein (Fletcher factor) by
factor XIIa.
Plasma prekallikrein is a
glycoprotein that parti****tes in the...
-
collagen by high-molecular-weight
kininogen (HMWK),
prekallikrein, and FXII (Hageman factor).
Prekallikrein is
converted to
kallikrein and FXII
becomes FXIIa...
-
antiangiogenic properties;
binding to
negatively charged surfaces Domain 6 -
prekallikrein and
factor XI
binding (amino
acids 420 to 510)(histidine rich) HMWK...
- FXIIa, FXI is a
member of the "contact pathway" (which
includes HMWK,
prekallikrein,
factor XII,
factor XI, and
factor IX).
Factor XIa
activates factor...
- themselves.[citation needed] HMWK is
produced by the
liver together with
prekallikrein (see below). It acts
mainly as a
cofactor on
coagulation and inflammation...
- and is part of the
coagulation cascade. It
activates factor XI and
prekallikrein in vitro. FXII is
activated to
FXIIa by
negatively charged surfaces...
-
enzyme has been
shown to be an
activator of the cell matrix-****ociated
prekallikrein. The
importance of
angiotensin II, one of the
substrates of this enzyme...
-
binds to
prekallikrein messenger RNA (mRNA) and
degrades it by
means of
ribonuclease H1,
which results in the
reduced production of
prekallikrein protein...
-
activation system or CAS,
three proteins in the blood,
factor XII (FXII),
prekallikrein (PK) and high
molecular weight kininogen (HK), bind to a
surface and...
