-
steroids stemming from 5α-
pregnane (originally allopregnane) and 5β-
pregnane (17β-ethyletiocholane). It has a
gonane core. 5β-
Pregnane is the
parent of pregnanediones...
-
virilization of the male fetus.
Allopregnanolone is an
endogenous inhibitory pregnane neurosteroid. It is made from pregnenolone, and is a
positive allosteric...
- In the
field of
molecular biology, the
pregnane X
receptor (PXR), also
known as the
steroid and
xenobiotic sensing nuclear receptor (SXR) or
nuclear receptor...
- 5α-
Pregnane-3α,17α-diol-20-one, also
known as 17α-hydroxyallopregnanolone (17-OH-allo) is an
endogenous steroid. 5α-
Pregnane-3α,17α-diol-20-one is a metabolite...
- derivatives. It is one of the
epimers of
pregnane, the
other being 5α-
pregnane.
Derivatives of 5β-
pregnane include the
naturally occurring steroids...
-
complexity renders the CYP3A4 gene more
sensitive to
endogenous and
exogenous pregnane X
receptor (PXR) and
constitutive androstane receptor (CAR) ligands, instead...
- [citation needed] It has been
found to act as an
agonist of the
human pregnane X
receptor ligand-binding
domain and to
induce CYP3A4
expression in vitro...
-
serves as a skeleton.
These parent structures have
specific names, such as
pregnane, androstane, etc. The
derivatives carry various functional groups called...
- Allopregnane, also
known as 5α-
pregnane or as 10β,13β-dimethyl-17β-ethyl-5α-gonane, is a
steroid and a
parent compound of a
variety of
steroid derivatives...
- nasopharyngitis, and
urinary tract infection. An
orally active inhibitory pregnane neurosteroid,
zuranolone acts as a
positive allosteric modulator of the...
