-
isomers being pregnanolone (5β-
pregnan-3α-ol-20-one),
isopregnanolone (5α-
pregnan-3β-ol-20-one), and
epipregnanolone (5β-
pregnan-3β-ol-20-one). The biosynthesis...
- SAGE-547): 5α-
pregnan-3α-ol-20-one –
GABAA receptor positive allosteric modulator Dihydrodeoxycorticosterone (DHDOC): 21-hydroxy-5α-
pregnan-20-one – GABAA...
- "20-one" suffix). However,
erroneous use of
suffixes can be found, e.g., "5α-
pregnan-17α-diol-3,11,20-trione" [sic] —
since it has just one
hydroxy group (at...
- 5α-Dihydroprogesterone (5α-DHP, allopregnanedione, or 5α-pregnane-3,20-dione) is an
endogenous progestogen and
neurosteroid that is
synthesized from progesterone...
-
sepranolone (INNTooltip
International Nonproprietary Name), and as 3β-hydroxy-5α-
pregnan-20-one or 3β,5α-tetrahydroprogesterone (3β,5α-THP), is an
endogenous neurosteroid...
- 5α-
Pregnan-17α-ol-3,20-dione, also
known as 17α-hydroxy-dihydroprogesterone (17-OH-DHP) is an
endogenous steroid, a
metabolite of 17α-hydroxyprogesterone...
- 5alpha-
pregnan-3,20-dione + NADP+ ⇌ {\displaystyle \rightleftharpoons }
progesterone +
NADPH + H+ Thus, the two
substrates of this
enzyme are 5alpha-
pregnan-3...
- of
progesterone and
allopregnanolone and an
isomer of
pregnanediol (5β-
pregnan-3α,20α-diol). It has been
found to act like a
partial agonist of an allosteric...
-
reaction pregnan-21-ol + NAD+ ⇌ {\displaystyle \rightleftharpoons }
pregnan-21-al + NADH + H+ Thus, the two
substrates of this
enzyme are
pregnan-21-ol and...
-
follows (depending on the
initial substrate): 17α-hydroxyprogesterone → 5α-
pregnan-17α-ol-3,20-dione → 5α-pregnane-3α,17α-diol-20-one →
androsterone → 5α-androstane-3α...