-
constructs to
identify the most immunogenic, and
constructed a
bivalent RSV
prefusion F
investigational vaccine. In
February 2023,
results of a
phase III study...
-
independently of G. F
protein exists in
multiple conformational forms. In the
prefusion state (PreF), the
protein exists in a
trimeric form and
contains the major...
-
exists in two conformations: a
metastable prefusion form and a
stable postfusion form, with the
prefusion form
being a
major target for neutralizing...
-
McLellan JS (March 2020). "Cryo-EM
structure of the 2019-nCoV
spike in the
prefusion conformation". Science. 367 (6483): 1260–1263. Bibcode:2020Sci...367.1260W...
-
synthetic vaccines use a 2P
mutation to lock the
spike protein into its
prefusion configuration,
stimulating an
adaptive immune response to the
virus before...
- S. (March 13, 2020). "Cryo-EM
Structure of the 2019-nCoV
Spike in the
Prefusion Conformation". Science. 367 (6483): 1260–1263. Bibcode:2020Sci...367.1260W...
-
shape after,
known as the
prefusion and
postfusion conformations.
Antibodies that
recognize spike proteins in the
prefusion shape are much more effective...
-
replication defective Gorilla Adenovirus and
encodes for SARS-COV-2 full
length prefusion stabilized Spike protein. More specifically, the
vector used is the simian...
-
substitutions (K986P and V987P,
designated "2P") that
cause the
spike to
adopt a
prefusion-stabilized
conformation reducing the
membrane fusion ability, increasing...
- of parti****nts in
clinical trial NCT02878330.
Nirsevimab binds to the
prefusion conformation of the RSV
fusion (F) protein, i.e. it
binds to the site...
