-
normal form of the
protein is
called PrPC,
while the
infectious form is
called PrPSc – the C
refers to 'cellular'
PrP,
while the Sc
refers to 's****ie'...
-
multiple isoforms: the
normal PrPC form, and the protease-resistant form
designated PrPRes such as the disease-causing
PrPSc (s****ie) and an
isoform located...
-
cellular PrPC into
PrPSc.
Evidence for this hypothesis:
Infectivity titre correlates with
PrPSc levels. However, this is disputed.
PrPSc is an
isomer of
PrPC...
-
suggested that pre-existing or
acquired PrPsc can
promote the
conversion of
PrPc into
PrPsc,
which goes on to
convert other PrPc. This
initiates a
chain reaction...
- 626 days, and
these mice had the protease-resistant form
PrpSc, of a host-coded glycoprotein,
PrPc . The protease-resistant form is a
marker of TSE disease...
- and some
specific antibodies against PrPSc. The
technique allowed improved detection and
testing time for
PrPSc. In 2014, a
human study showed a nasal...
-
normal brain prion protein (
PrP) into the toxic, disease-related
PrPSc form has started. At present, no way is
known to
detect PrPSc reliably except by examining...
-
capable of
converting normally folded prion protein,
PrPC ("C" for cellular) into an
abnormal form,
PrPSc ("Sc" for s****ie), thus
leading to a
chain reaction...
-
prior to
presentation of symptoms. However,
PrPSc levels are very low in
presymptomatic hosts. In addition,
PrPScs are
generally unevenly distributed in body...
-
oligomeric infectious PrPSc. PMCA
possesses the
ability to
generate millions infectious units,
starting with the
equivalent to one
PrPSc oligomer; well below...
