- naturally-occurring
polyketides and
evolution of new
polyketides with
novel or
improved bioactivity.
Naturally produced polyketides by
various plants and...
-
Polyketide synthases (PKSs) are a
family of multi-domain
enzymes or
enzyme complexes that
produce polyketides, a
large class of
secondary metabolites...
- also
known as the
polyketide pathway, is a
fundamental biosynthetic route in
organisms for the
production of
fatty acids and
polyketides. This
pathway operates...
-
Aromatic polyketides are ****embled by a type II (iterative)
polyketide synthase in bacteria.
Iterative type II
polyketide syntheses produce polyketide chains...
- glycerolipids, glycerophospholipids, sphingolipids, saccharolipids, and
polyketides (derived from
condensation of
ketoacyl subunits); and
sterol lipids and...
- into four
major classes: terpenes,
phenylpropanoids (i.e. phenolics),
polyketides, and alkaloids.
Terpenes constitute a
large class of
natural products...
- Due to the
similarity with
polyketide synthases (PKS), many
secondary metabolites are, in fact,
fusions of NRPs and
polyketides. In essence, this occurs...
-
polyketide are in RapC. Then, the
linear polyketide is
modified by the NRPS, RapP,
which attaches L-pipecolate to the
terminal end of the
polyketide,...
-
chemotherapeutic drugs. In 2009, a
study showed that O.
unilateralis also
produces polyketides.
These secondary metabolites have been used in
antibiotics such as patulin...
-
Proteins Glycoproteins &
proteoglycans Chlorophylls MEP MVA
Acetyl -CoA
Polyketides Terpenoid backbones Terpenoids &
carotenoids (vitamin A) Cholesterol...
