- naturally-occurring
polyketides and
evolution of new
polyketides with
novel or
improved bioactivity.
Naturally produced polyketides by
various plants and...
-
Polyketide synthases (PKSs) are a
family of multi-domain
enzymes or
enzyme complexes that
produce polyketides, a
large class of
secondary metabolites...
- also
known as the
polyketide pathway, is a
fundamental biosynthetic route in
organisms for the
production of
fatty acids and
polyketides. This
pathway operates...
-
class of
aromatic polyketide antibiotics, also
known as
bacterial aromatic polyketides,
produced by
Streptomyces via type II
polyketide synthases (PKSs)...
- into four
major classes: terpenes,
phenylpropanoids (i.e. phenolics),
polyketides, and alkaloids.
Terpenes constitute a
large class of
natural products...
- Due to the
similarity with
polyketide synthases (PKS), many
secondary metabolites are, in fact,
fusions of NRPs and
polyketides. In essence, this occurs...
- glycerolipids, glycerophospholipids, sphingolipids, saccharolipids, and
polyketides (derived from
condensation of
ketoacyl subunits); and
sterol lipids and...
-
Xiaokun (2023-04-21). "Engineered
Biosynthesis of
Complex Disorazol Polyketides in a
Streamlined Burkholderia thailandensis". ACS
Synthetic Biology....
-
Hutchinson CR (2001). "Production of
aromatic minimal polyketides by the
daunorubicin polyketide synthase genes reveals the
incompatibility of the heterologous...
-
chemotherapeutic drugs. In 2009, a
study showed that O.
unilateralis also
produces polyketides.
These secondary metabolites have been used in
antibiotics such as patulin...
