-
polyQ tract, and the ac****ulation of
polyQ proteins damages key
cellular functions such as the ubiquitin-proteasome system. A
common symptom of
polyQ...
-
PolyQ is a
biological database of
polyglutamine repeats in
disease and non-disease ****ociated proteins.
Trinucleotide repeat disorder Robertson, Amy L;...
- A
polyglutamine tract or
polyQ tract is a
portion of a
protein consisting of a
sequence of
several glutamine units. A
tract typically consists of about...
-
tract (or
polyQ tract), and the
repeated part of the gene, the
polyQ region. Generally,
people have
fewer than 36
repeated glutamines in the
polyQ region...
- for the
amino acid glutamine. A
repeat of CAG
results in a
polyglutamine (
polyQ) tract.
Diseases ****ociated with such
mutations are
known as trinucleotide...
- ataxia.
Common characteristics of
polyglutamine (or
polyQ)
diseases is the ac****ulation of
polyQ proteins and the
progressive degeneration of
nerve cells...
-
efficacious in
other SCA
treatments that have
similar pathology related to
PolyA and
PolyQ diseases. In addition, Dr.
Beverly Davidson has been
working on a methodology...
-
cyprinid fishes.
Polymorphisms in the gene
mainly affect the
length of the
PolyQ domain region,
providing an
example of
divergent evolution where species...
-
diseases that are
caused by
expanded CAG
repeats encoding polyglutamine (
polyQ)
stretches (see:
Trinucleotide repeat disorder). The
expanded CAG repeats...
-
poly-
Q dependent aggregation and
neurodegeneration in cell cultures, yeast, fly, and
mouse models, and
deletion of hsp70
increased the size of
polyQ inclusion...
