-
Pneumolysin is a
virulence factor of the Gram-positive
bacteria Streptococcus pneumoniae. It is a pore-forming
toxin of 53 kDa
composed of 471
amino acids...
- Pro-inflammatory
effects are
exhibited by the
single pneumococcal toxin,
pneumolysin (Ply); use of anti-Ply
antibodies result in
decreased inflammation. Studies...
- when the
immune system of the host is suppressed. Invasins, such as
pneumolysin, an
antiphagocytic capsule,
various adhesins, and
immunogenic cell wall...
-
pneumolysin,
which is
released from the
cytoplasm of
Streptococcus pneumoniae when the
bacteria lyse. The CDCs
Streptococcus pneumoniae Pneumolysin,...
- host
immune cells by
inhibiting C3b
opsonization of the
bacterial cells Pneumolysin (Ply)—a 53-kDa pore-forming
protein that can
cause lysis of host cells...
- proliferation, phagocytosis, and
proinflammatory cytokine release. CDCs, such as
pneumolysin, from S. pneumoniae, form
pores as
large as 260Å (26 nm), containing...
- E. coli α-hemolysin,
Aeromonas aerolysin) to 25–30 nm (streplysin O,
pneumolysin).
Depending on how the
pores are formed, the pore
forming cytolysins...
- HR (2005). "Structural
basis of pore
formation by the
bacterial toxin pneumolysin". Cell. 121 (2): 247–56. doi:10.1016/j.cell.2005.02.033. PMID 15851031...
-
shared by all CDCs,
which essentially corresponds to the
sequence of
pneumolysin, the
shortest member of the family. CDCs with
longer sequences usually...
-
Gerber J,
Spreer A, Bähr M,
Michel U, Nau R (2002). "Neurotoxicity of
pneumolysin, a
major pneumococcal virulence factor,
involves calcium influx and depends...
