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Pleiotropy (from Gr**** πλείων pleion, 'more', and τρόπος tropos, 'way') is a
phenomenom in
genetics where a gene, or a
single genetic variant, affects...
- The
antagonistic pleiotropy hypothesis (APT) is a
theory in
evolutionary biology that
suggests certain genes may
confer beneficial effects early in an...
- In pharmacology,
pleiotropy includes all of a drug's
actions other than
those for
which the
agent was
specifically developed. It may
include adverse effects...
- of
mutations (evolution of ageing),
disposable soma and
antagonistic pleiotropy hypothesis. The
molecular theories of
ageing include phenomena such as...
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pleiotropy in the interleukin-4/13 system", Cell, 132(2):259-72. Ozaki, K; Leonard, WJ (16
August 2002). "Cytokine and
cytokine receptor pleiotropy and...
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better explained as a by-product of
adaptive traits caused by
antagonistic pleiotropy and by
genes that are
retained due to a
fitness landscape with an asymmetric...
- ****tive
cause for the
broad changes seen in
domestication syndrome is
pleiotropy.
Pleiotropy occurs when one gene
influences two or more
seemingly unrelated...
-
evolution such as kin
selection and
inclusive fitness, or
antagonistic pleiotropy that
favors heterozygotes causing homo****uality
among homozygotes as a...
-
Biology of
Aging exploring a view of the
subject based on
antagonistic pleiotropy, the
hypothesis that
aging is
caused by
genes that have two effects, one...
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would include information about the patient's covariates.
Every novel pleiotropy discovery will need
further biological validation to
ensure that the data-driven...
