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Platensimycin, a
metabolite of
Streptomyces platensis, is an antibiotic,
which acts by
blocking the
enzymes β-ketoacyl-(acyl-carrier-protein (ACP)) synthase...
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inhibiting the
acetylcholine esterase.
Scientists at
Merck discovered platensimycin, a
novel antibiotic lead
compound with
potential medicinal applications...
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isolated from soil.
Streptomyces platensis produces oxytetracycline,
platensimycin, migrastatin, isomigrastatin, platencin,
dorrigocin A,
dorrigocin B...
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isoleucine t-RNA
synthetase (IleRS)
causing inhibition of
protein synthesis Platensimycin Quinupristin/Dalfopristin
Synercid Thiamphenicol Gram-negative, Gram-positive...
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Escherichia coli, and
Streptoccoccus pneumonia. In
Escherichia coli,
platensimycin, thiolactomycin, and
iodoacetamide are also
known inhibitors. Optimal...
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antisteatotic effects of the
selective fatty acid
synthase (FAS)
inhibitor platensimycin in
mouse models of diabetes".
Proceedings of the
National Academy of...
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Lincomycin (Streptomyces lincolnensis)
Neomycin (Streptomyces fradiae)
Platensimycin (Streptomyces platensis)
Puromycin (Streptomyces alboniger) Spenolimycin...
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potentially useful antibiotic in its own right, it has now been
shown that
platensimycin is not
specifically active on mtFabH. It is
speculated that
novel inhibitors...
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mimics malonyl ACP in the
active site, can only
inhibit FabB. Lastly,
platensimycin also has
possible antibiotic use due to its
inhibition of FabF. These...
