-
Platensimycin, a
metabolite of
Streptomyces platensis, is an antibiotic,
which acts by
blocking the
enzymes β-ketoacyl-(acyl-carrier-protein (ACP)) synthase...
-
inhibiting the
acetylcholine esterase.
Scientists at
Merck discovered platensimycin, a
novel antibiotic lead
compound with
potential medicinal applications...
-
isoleucine t-RNA
synthetase (IleRS)
causing inhibition of
protein synthesis Platensimycin Quinupristin/Dalfopristin
Synercid Thiamphenicol Gram-negative, Gram-positive...
-
isolated from soil.
Streptomyces platensis produces oxytetracycline,
platensimycin, migrastatin, isomigrastatin, platencin,
dorrigocin A,
dorrigocin B...
-
antisteatotic effects of the
selective fatty acid
synthase (FAS)
inhibitor platensimycin in
mouse models of diabetes".
Proceedings of the
National Academy of...
-
Escherichia coli, and
Streptoccoccus pneumonia. In
Escherichia coli,
platensimycin, thiolactomycin, and
iodoacetamide are also
known inhibitors. Optimal...
-
Lincomycin (Streptomyces lincolnensis)
Neomycin (Streptomyces fradiae)
Platensimycin (Streptomyces platensis)
Puromycin (Streptomyces alboniger) Spenolimycin...
-
mimics malonyl ACP in the
active site, can only
inhibit FabB. Lastly,
platensimycin also has
possible antibiotic use due to its
inhibition of FabF. These...
-
potentially useful antibiotic in its own right, it has now been
shown that
platensimycin is not
specifically active on mtFabH. It is
speculated that
novel inhibitors...