-
Pitolisant, sold
under the
brand name
Wakix among others, is a
medication used for the
treatment of
excessive daytime sleepiness in
adults with narcolepsy...
- the brain.
Pitolisant is an
histamine 3 (H3)-receptor
inverse agonist. As
histamine 3 (H3)
receptors mainly act as autoreceptors,
pitolisant decreases...
-
These medications include alerting agents (e.g., modafinil, armodafinil,
pitolisant, solriamfetol),
oxybate medications (e.g.,
twice nightly sodium oxybate...
- ABT-239, ciproxifan, conessine, A-349,821, enerisant, betahistine, and
pitolisant. The
histamine H3
receptor (H3R) was
discovered in 1983 and was one of...
- long QT syndrome, by
certain medications such as fluconazole,
sotalol or
pitolisant, by
disturbances in the
concentrations of
certain salts within the blood...
-
histamine release in hypothalamus. An
inverse agonist of the
histamine H3 is
Pitolisant.
Results after testing on
animals have
indicated increased wakefulness...
- may cure the
person from the EDS.
Drugs like modafinil, armodafinil,
pitolisant (Wakix),
sodium oxybate (Xyrem) oral solution, have been
approved as treatment...
- or
sodium oxybate (as
first line);
methylphenidate and
pitolisant (as
second line [
pitolisant is
currently only
available in Europe]); and amphetamines...
-
istradefylline Histamine H3
receptor antagonists and
inverse agonists like
pitolisant and
samelisant Orexin receptor agonists like
danavorexton and suntinorexton...
- agonists:
Loratadine Histamine 3 (H3)
receptor antagonists/inverse agonists:
Pitolisant SERM (selective
estrogen receptor modulators)
Raloxifene Vasodilators...
