-
Phospholamban, also
known as PLN or PLB, is a
micropeptide protein that in
humans is
encoded by the PLN gene.
Phospholamban is a 52-amino acid integral...
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releasing the Ca2+ into the SR. A
protein found in
cardiac muscle,
called phospholamban (PLB) has been
shown to
prevent SERCA from working. It does this by...
- and
phosphorylates numerous targets, namely: L-type
calcium channels,
phospholamban,
troponin I,
myosin binding protein C, and pot****ium channels. This...
- up by the mitochondria. An enzyme,
phospholamban,
serves as a
brake for SERCA. At low
heart rates,
phospholamban is
active and
slows down the activity...
-
effects including phosphorylating phospholamban (via
Protein kinase A).
Phosphorylating phospholamban. When
phospholamban is not phosphorylated, it inhibits...
- (SERCA) by
binding to
transmembrane helices alone or in ****ociation with
phospholamban".
Proceedings of the
National Academy of
Sciences of the
United States...
- by
phospholamban and
higher phospholamban-to-SERCA2a
ratios cause SERCA inhibition and
impaired relaxation.
Istaroxime reduces SERCA2a-
phospholamban interaction...
- genotype-phenotype ****ociations in DCM and
mutations in
lamin (LMNA),
phospholamban (PLN), RNA
Binding Motif Protein 20 (RBM20),
Cardiac Myosin Binding...
-
several targets, such as
phospholamban, LTCC,
Troponin I (TnI), and pot****ium channels. The
phosphorylation of
phospholamban deactivates its own function...
-
calcium ATPase (five
different conformations)
Calcium ATPase regulators phospholamban and
sarcolipin ABC
transporters General secretory pathway (Sec) translocon...
