-
numerous less-well-characterized small-molecule
phosphodiesterases. The
cyclic nucleotide phosphodiesterases comprise a
group of
enzymes that
degrade the...
- PMID 17933689. Francis, SH; Conti, M; Houslay, MD, eds. (2011).
Phosphodiesterases as Drug
Targets (PDF).
Handbook of
Experimental Pharmacology. Vol...
-
preferentially inhibit PDE5, the
degree to
which they also
inhibit other phosphodiesterases influences their side
effect profile. For example,
sildenafil also...
-
types of the
enzyme phosphodiesterase 4 (PDE4) are known: PDE4A PDE4B PDE4C PDE4D 3',5'-cyclic-AMP
phosphodiesterase Phosphodiesterase (PDE) PDE4 inhibitor...
- 3′,5′-cyclic-nucleotide
phosphodiesterases (EC 3.1.4.17) are a
family of
phosphodiesterases. Generally,
these enzymes hydrolyze a
nucleoside 3′,5′-cyclic...
-
selective for PDE5. Its
effect is more
potent on PDE5 than on
other known phosphodiesterases (10-fold for PDE6, >80-fold for PDE1, >700-fold for PDE2, PDE3, PDE4...
- (1976). "Properties and drug
responsiveness of
cyclic nucleotide phosphodiesterases of rat lung". Mol. Pharmacol. 12 (4): 678–687. PMID 183099. Weiss...
-
Sibley D (September 2010). "cGMP-dependent
protein kinases and cGMP
phosphodiesterases in
nitric oxide and cGMP action".
Pharmacological Reviews. 62 (3):...
- (breaking) of
phosphodiester bonds can be
promoted in
several ways.
Phosphodiesterases are
enzymes that
catalyze the
hydrolysis of the
phosphodiester bond...
- as hormones, light, and neurotransmitters. The
cyclic nucleotide phosphodiesterases (PDEs)
regulate the
cellular concentrations of
cyclic nucleotides...
