-
numerous less-well-characterized small-molecule
phosphodiesterases. The
cyclic nucleotide phosphodiesterases comprise a
group of
enzymes that
degrade the...
- (1976). "Properties and drug
responsiveness of
cyclic nucleotide phosphodiesterases of rat lung". Mol. Pharmacol. 12 (4): 678–687. PMID 183099. Weiss...
-
types of the
enzyme phosphodiesterase 4 (PDE4) are known: PDE4A PDE4B PDE4C PDE4D 3',5'-cyclic-AMP
phosphodiesterase Phosphodiesterase (PDE) PDE4 inhibitor...
-
inhibitor Bender AT,
Beavo JA (September 2006). "Cyclic
nucleotide phosphodiesterases:
molecular regulation to
clinical use".
Pharmacological Reviews. 58...
- 3′,5′-cyclic-nucleotide
phosphodiesterases (EC 3.1.4.17) are a
family of
phosphodiesterases. Generally,
these enzymes hydrolyze a
nucleoside 3′,5′-cyclic...
- PMID 17933689. Francis, SH; Conti, M; Houslay, MD, eds. (2011).
Phosphodiesterases as Drug
Targets (PDF).
Handbook of
Experimental Pharmacology. Vol...
-
selective for PDE5. Its
effect is more
potent on PDE5 than on
other known phosphodiesterases (10-fold for PDE6, >80-fold for PDE1, >700-fold for PDE2, PDE3, PDE4...
-
sulfuryl transfer reactions. This
group includes phosphomonoesterases,
phosphodiesterases,
phosphoglycerate mutases, phosphophenomutases, and sulfatases. Zalatan...
- The PDE2 (
phosphodiesterase 2)
enzyme is one of 21
different phosphodiesterases (PDE)
found in mammals.
These different PDEs can be
subdivided to 11 families...
-
preferentially inhibit PDE5, the
degree to
which they also
inhibit other phosphodiesterases influences their side
effect profile. For example,
sildenafil also...
