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Phorbol is a natural, plant-derived
organic compound. It is a
member of the
tigliane family of diterpenes.
Phorbol was
first isolated in 1934 as the hydrolysis...
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diterpenoid phorbol.
Protein kinase C (PKC) is a
phorbol ester receptor.
Phorbol esters can
stimulate PKC in a
similar way to diglycerides.
Phorbol esters...
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enzyme phorbol-diester
hydrolase (EC 3.1.1.51)
catalyzes the
reaction phorbol 12,13-dibutanoate + H2O ⇌ {\displaystyle \rightleftharpoons }
phorbol 13-butanoate...
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Wender group reported an
efficient semi-synthesis of
tigilanol tiglate from
phorbol (12%
overall yield over 12 steps).
Tigilanol tiglate was
approved for use...
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tetradecanoylphorbol acetate,
tetradecanoyl phorbol acetate, and
phorbol 12-myristate 13-acetate (PMA) is a
diester of
phorbol. It is a
potent tumor promoter often...
- of the
chemical compound phorbol.
Tumor promotion activity was
traced to
phorbol esters present in
croton oil. Pure
phorbol 12-myristate 13-acetate, which...
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phytohaemagglutinin (PHA) or
other stimulants such as
phorbol 12-myristate 13-acetate (PMA or
simply phorbol),
express interleukin 2, and are used in research...
- in the
Euphorbiaceae family. It is a
spurge native to
southern Africa.
Phorbol has been
isolated from the
latex of this
perennial plant.
Wikimedia Commons...
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crotonic acid [citation needed],
crotonic resin, and
various co-carcinogenic
phorbol derivatives. "Croton tiglium".
Germplasm Resources Information Network...
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structural basis for some
natural chemical compounds such as
phorbol.
Abietane Labdane Ingenane Phorbol esters Tigilanol tiglate "Tigliane", Pubchem, retrieved...
