- MPP+ (1-methyl-4-
phenylpyridinium) is a
positively charged organic molecule with the
chemical formula C12H12N+. It is a
monoaminergic neurotoxin that acts...
-
inside the brain, MPTP is
metabolized into the
toxic cation 1-methyl-4-
phenylpyridinium (MPP+) by the
enzyme monoamine oxidase B (MAO-B) of
glial cells, specifically...
-
Kalgutkar AS,
Nguyen HT (September 2004). "Identification of an N-methyl-4-
phenylpyridinium-like
metabolite of the
antidiarrheal agent loperamide in
human liver...
-
effects of the toxin.
Annonacin is 100
times more
toxic than 1-methyl-4-
phenylpyridinium (MPP+),
another potent mitochondrial complex I inhibitor. Compared...
- & 12)],
methylenedioxy methamphetamine [METH (13)] and N-methyl-4-
phenylpyridinium (15) are all more
potent inhibitors of VMAT2...
Miller GM (January...
- temperature. Consequently, he
produced MPTP as a
major impurity. 1-Methyl-4-
phenylpyridinium (MPP+), a
metabolite of MPTP,
causes rapid onset of
irreversible symptoms...
-
system (astrocytes)
include MAO-B that
oxidizes MPTP to 1-methyl-4-
phenylpyridinium (MPP+),
which is toxic. MPP+
eventually travels to the extracellular...
- be
accidentally produced during the
manufacture of MPPP. 1-Methyl-4-
phenylpyridinium (MPP+), a
metabolite of MPTP,
causes rapid onset of
irreversible symptoms...
-
gluconeogenesis in the
cytoprotection of
neuroblastoma cells against 1-methyl 4-
phenylpyridinium ion toxicity". Neurotoxicology. 24 (1): 137–47. doi:10.1016/S0161-813X(02)00110-9...
- Marvell,
Elliot N.; Caple, Gerald; Shahidi, Iraj (1970). "Formation of
phenylpyridinium chloride from 5-anilino-N-phenyl-2,4-pentadienylideniminium chloride...
