Definition of Perforins. Meaning of Perforins. Synonyms of Perforins

- Perforin-1 Perforin (PRF), encoded by the PRF1 gene, is a pore-forming toxic protein housed in the secretory granules of cytotoxic T lymphocytes (CTLs)...
- and become harmful. Tests have shown that mice without granzymes and perforins are at high risk to have tumors spread throughout their body. Tumors have...
- chemokines (IP-10, lymphotactin), trigger cytolysis of target cells (perforins, granzymes...), and interact with other cells, such as epithelial cells...
- protein pathway. In this pathway perforins and granzymes are taken up by the target cell. In this pathway, the perforins facilitate the entry of granule...
- cells. It is secreted by these cells along with the pore forming protein perforin to mediate apoptosis in target cells. Granzyme B has also been found to...
- Stonustoxin (SNTX) is an extremely potent cytolytic toxin of the perforin-like superfamily. It is mainly found in stonefish (Synanceia). The name Stonustoxin...
- The Membrane Attack Complex/Perforin (MACPF) superfamily, sometimes referred to as the MACPF/CDC superfamily, is named after a domain that is common to...
- be triggered by activated T cells – which secrete toxic granzymes and perforin – or indirectly as a result of reduced blood flow or the generation of...
- activated T cell contacts such cells, it releases cytotoxins, such as perforin, which form pores in the target cell's plasma membrane, allowing ions,...
- proteins such as perforin and proteases known as granzymes. Upon release in close proximity to a cell slated for killing, perforin forms pores in the...