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Perforin-1
Perforin (PRF),
encoded by the PRF1 gene, is a pore-forming
toxic protein housed in the
secretory granules of
cytotoxic T
lymphocytes (CTLs)...
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cells and T cells,
granzymes are
packaged in
cytotoxic granules along with
perforin.
Granzymes can also be
detected in the
rough endoplasmic reticulum, golgi...
- cells. It is
secreted by
these cells along with the pore
forming protein perforin to
mediate apoptosis in
target cells.
Granzyme B has also been
found to...
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chemokines (IP-10, lymphotactin),
trigger cytolysis of
target cells (
perforins, granzymes...), and
interact with
other cells, such as
epithelial cells...
- The
Membrane Attack Complex/
Perforin (MACPF) superfamily,
sometimes referred to as the MACPF/CDC superfamily, is
named after a
domain that is
common to...
-
proteins such as
perforin and
proteases known as granzymes. Upon
release in
close proximity to a cell
slated for killing,
perforin forms pores in the...
- FHL are each ****ociated with a
specific gene: FHL1: HPLH1 FHL2: PRF1 (
Perforin) FHL3: UNC13D (Munc13-4) FHL4: STX11 (Syntaxin 11) FHL5: STXBP2 (Syntaxin...
- be
triggered by
activated T
cells –
which secrete toxic granzymes and
perforin – or
indirectly as a
result of
reduced blood flow or the
generation of...
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Stonustoxin (SNTX) is an
extremely potent cytolytic toxin of the
perforin-like superfamily. It is
mainly found in
stonefish (Synanceia). The name Stonustoxin...
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Status Antigens Positive CD2, CD3ε, CD56,
perforin,
granzyme B, TIA-1, CCR5
Negative CD57...
