-
monoclonal protein, M protein, M component, M spike,
spike protein, or
paraprotein. This
proliferation of the
myeloma protein has
several deleterious effects...
- of
paraprotein is the
Bence Jones protein,
which is a
urinary paraprotein composed of free
light chains.
Quantitative measurements of the
paraprotein are...
- bone
marrow (<5%
plasma cells),
normal skeletal survey,
absent or low
paraprotein and no end
organ damage. For SPB the most
common presenting symptom is...
-
symmetrical and length-dependent. It is
frequently linked to an IgM
paraprotein and
noticeably longer distal motor latencies. The
characteristics are...
- with MGUS if they
fulfill the
following four criteria: A
monoclonal paraprotein band less than 30 g/L (< 3g/dL);
Plasma cells less than 10% on bone marrow...
- this
spectrum of diseases, a
clone of
plasma cells secreting monoclonal paraprotein (also
termed myeloma protein or M protein)
causes the
relatively benign...
-
which is why they are also
known as gammaglobulins. The
majority of
paraproteins appear in this band.
Paraproteinemias may be
categorized according to...
-
complement The
gamma (γ) band -
immunoglobulin (IgA, IgD, IgE, IgG and IgM).
Paraproteins (in
multiple myeloma)
usually appear in this band.
Affinity electrop****sis...
-
hyperviscosity of the plasma. This is
especially likely with IgM-class
paraproteins, and to a
lesser extent, IgA-class. The
basal ESR is
slightly higher...
- headache, and (rarely)
stroke or coma are due to the
effects of the IgM
paraprotein,
which may
cause autoimmune phenomena or cryoglobulinemia.
Other symptoms...
