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Paraoxonases are a
family of
mammalian enzymes with
aryldialkylphosphatase activity.
There are
three paraoxonase isozymes,
which were
originally discovered...
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Paraoxonase 1 (PON1) also
known as
Serum paraoxonase and
arylesterase 1, A esterase,
homocysteine thiolactonase or
serum aryldialkylphosphatase 1, is an...
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cyclic AMP system; and
influence other chemical pathways. The
enzyme paraoxonase 1 (PON1)
detoxifies chlorpyrifos oxon, the more
toxic metabolite of chlorpyrifos...
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August 2018.
Draganov DI, La Du BN (January 2004). "Pharmacogenetics of
paraoxonases: a
brief review". Naunyn-Schmiedeberg's
Archives of Pharmacology. 369...
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Gaidukov L,
Yagur S, et al. (2004). "Directed
evolution of
mammalian paraoxonases PON1 and PON3 for
bacterial expression and
catalytic specialization"...
- over the next decade. The
first linkage between CF and
another marker (
paraoxonase) was
found in 1985 by Hans Eiberg,
indicating that only one
locus exists...
- its
identity as a
prodrug of GHB. GBL is
rapidly converted into GHB by
paraoxonase (lactonase) enzymes,
found in the blood.
Animals which lack
these enzymes...
-
Teiber JF,
Speelman A,
Osawa Y,
Sunahara R, La Du BN (June 2005). "Human
paraoxonases (PON1, PON2, and PON3) are
lactonases with
overlapping and
distinct substrate...
- rid of them."
Another mechanism may be the
increase in
activities of
paraoxonases by
dietary antioxidants which can
reduce oxidative stress.
Vitamin A...
-
cholinergic synapses and can only be
reactivated very slowly, if at all.
Paraoxonase 1 (PON1) is a key
enzyme involved in
organophosphate toxicity and has...
