- used is
calcium pantothenate,
because chemically it is more stable, and
hence makes for
longer product shelf-life, than
sodium pantothenate and free pantothenic...
- thioester) as a substrate. In humans, CoA
biosynthesis requires cysteine,
pantothenate (vitamin B5), and
adenosine triphosphate (ATP). In its
acetyl form, coenzyme...
-
Pantothenate kinase-****ociated
neurodegeneration (PKAN),
formerly called Hallervorden–Spatz syndrome, is a
genetic degenerative disease of the
brain that...
-
Pantothenate kinase (EC 2.7.1.33, PanK; CoaA) is the
first enzyme in the
Coenzyme A (CoA)
biosynthetic pathway. It
phosphorylates pantothenate (vitamin...
-
Pantothenate kinase 2,
mitochondrial is an
enzyme that in
humans is
encoded by the PANK2 gene. This gene
encodes a
protein belonging to the pantothenate...
- (R)-
pantothenate + H2O ⇌ {\displaystyle \rightleftharpoons } (R)-pantoate + beta-alanine Thus, the two
substrates of this
enzyme are (R)-
pantothenate and...
-
Ardinger HH,
Pagon RA,
Wallace SE, Bean LJ,
Stephens K,
Amemiya A (eds.). "
Pantothenate Kinase-****ociated Neurodegeneration".
GeneReviews [Internet]. PMID 20301663...
-
Harden ME, et al. (January 2024). "
Pantothenate Kinase Activation Restores Brain Coenzyme A in a
Mouse Model of
Pantothenate Kinase-****ociated Neurodegeneration"...
-
Ottenhof HH,
Whitney HM,
Blundell TL,
Abell C, et al. (August 2005). "
Pantothenate biosynthesis in
higher plants".
Biochemical Society Transactions. 33...
-
genetic conditions such as Huntington's disease, neuroacanthocytosis,
pantothenate kinase-****ociated neurodegeneration,
Duchenne muscular dystrophy, Wilson's...
