-
chimera (
PROTAC) is a
molecule that can
remove specific unwanted proteins.
Rather than
acting as a
conventional enzyme inhibitor, a
PROTAC works by inducing...
-
initial work
focused on the
discovery of PROteolysis-TArgeting
Chimeras (
PROTACs) to
trigger degradation of disease-causing proteins, a
process known as...
-
which is one of the
first examples of a
proteolysis targeting chimera or
PROTAC. It is a
bifunctional molecule with two
halves joined by a linker; one half...
-
operating companies in France, Italy, and the UK,
working with Bayern-Chemie/
Protac in Germany,
Inmize Sistemas SL in Spain, and Saab
Bofors Dynamics in Sweden...
-
several PROTACs degraders targeting the
androgen receptor have been
tested in the clinic:
Bavdegalutamide (ARV-110):
Developed by Arvinas, this
PROTAC is currently...
- of
PROTACs,
which consist of a
heterobifunctional molecule with a
ligand of an E3
ubiquitin ligase linked to a
ligand of a
target protein.
PROTACs are...
- the pool of
potential protein targets. Proteolysis-targeting
chimeras (
PROTACs) were
first reported by
Kathleen Sakamoto,
Craig Crews, and
Raymond Deshaies...
- (June 2022). "Phase 1b
study of bavdegalutamide, an
androgen receptor PROTAC degrader,
combined with
abiraterone in
patients with
metastatic prostate...
- Pulses".
Economic Botany. 61 (1): 108. doi:10.1663/0013-0001(2007)61[108a:
PROTAC]2.0.CO;2. ISSN 0013-0001. S2CID 198156564. McLelland,
Jonathan (4 December...
- proteolysis-targeting
chimera or
PROTAC and its
therapeutic potential.
Recruitment of an E3
ligase to the
target protein by the
PROTAC is a
critical step in the...
