-
receptors (
PPARs) are a
group of
nuclear receptor proteins that
function as
transcription factors regulating the
expression of genes.
PPARs play essential...
-
triglycerides and
blood sugar.
PPAR-alpha and
PPAR-gamma are the
molecular targets of a
number of
marketed drugs. The main
classes of
PPAR agonists are: An endogenous...
-
expression of
peroxisome proliferator-activated
receptors (
PPARs):
tissue distribution of
PPAR-alpha, -beta, and -gamma in the
adult rat". Endocrinology...
- genes.
Three subtypes of
PPARs are known:
PPAR-alpha,
PPAR-delta, and
PPAR-gamma. The
protein encoded by this gene is
PPAR-gamma and is a
regulator of...
-
fibrates activate peroxisome proliferator-activated
receptors (
PPARs),
especially PPARα. The
PPARs are a
class of
intracellular receptors that
modulate carbohydrate...
-
fibrate drugs,
which act on the
peroxisome proliferator-activated
receptors (
PPARs),
specifically PPARα, to
decrease free
fatty acid production.
Statin drugs...
- (affinity of 133 nM)
activation of
peroxisome proliferator-activated
receptors (
PPARs)
inhibition of
several tyrosine kinases inhibition of
topoisomerase inhibition...
-
transactivate peroxisome proliferator-activated
receptors (
PPARs). In
vitro studies show an
activation of
PPARs at
concentrations above 1 μM,
which is
higher than...
- S2CID 25098754.
Berger J,
Moller DE (2002). "The
mechanisms of
action of
PPARs".
Annual Review of Medicine. 53: 409–435. doi:10.1146/annurev.med.53.082901...
-
disease (atherosclerosis). However, not all
PPAR agonists are fibrates, not all triglyceride-lowering
agents are
PPAR agonists, and not all
drugs used to treat...
