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PIKfyve, a FYVE finger-containing
phosphoinositide kinase, is an
enzyme that in
humans is
encoded by the
PIKFYVE gene. The prin****l
enzymatic activity...
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Protein VAC14 homolog, also
known as Ar
PIKfyve (****ociated
Regulator of
PIKfyve), is a
protein that in
humans is
encoded by the VAC14 gene. The content...
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additional mode of action, as an
inhibitor of the
lipid kinase enzyme PIKfyve.
PIKfyve makes two lipids, PtdIns5P and PtdIns(3,5)P2,
whose syntheses are efficiently...
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PIKfyve,
called Ar
PIKfyve/VAC14, that
scaffolds a
ternary regulatory complex,
known as the PAS
complex (from the
first letters of
PIKfyve/Ar
PIKfyve/Sac3)...
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heterologous overexpression of the
enzymatically inactive PIKfyve point-mutant (
PIKfyveK1831E) and
PIKfyve silencing by
small interfering RNAs. Such a role is...
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inositol ring, and can be
converted to PtdIns(3,5)P2 by the
lipid kinase PIKfyve. Both FYVE
domains and PX
domains –
found in
proteins such as SNX1, HGS...
- hetero-oligomer with Ar
PIKfyve (gene symbol, VAC14) and this
binary complex ****ociates with the
phosphoinositide kinase PIKFYVE in a
ternary PAS complex...
- Stow JL,
Teasdale RD (April 2010). "Inhibition of the PtdIns(5)
kinase PIKfyve disrupts intracellular replication of Salmonella". The EMBO Journal. 29...
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named after the four cysteine-rich proteins: Fab 1 (yeast
orthologue of
PIKfyve), YOTB, Vac 1 (vesicle
transport protein), and EEA1, in
which it has been...
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Herrmann U, Losa M,
Marpakwar R,
Aguzzi A (September 2021). "Loss of
PIKfyve drives the
spongiform degeneration in
prion diseases". EMBO
Molecular Medicine...
