- a wide
range of cell types. The
protein is
encoded in the
human by the
PDGFRA gene. This
receptor binds to
certain isoforms of platelet-derived growth...
- as
tumors whose behavior is
driven by
mutations in the KIT gene (85%),
PDGFRA gene (10%), or BRAF
kinase (rare). 95% of
GISTs stain positively for KIT...
- a
study conducted in 2011 on
various Asian po****tions,
variants in the
PDGFRA gene on
chromosome 4q12 were
identified to be ****ociated with
corneal astigmatism...
-
receptor alpha gene (PGDFRA) gene. The
product of
PDGFRA, platelet-derived
growth factor receptor alpha (
PDGFRA), is a
tyrosine kinase receptor of the RTK class...
- and
lymphoid neoplasms ****ociated with
eosinophilia and
abnormalities of
PDGFRA, PDGFRB, FGFR1, and, tentatively, PCMA-JAK2. Informally,
these diseases...
-
harboring the platelet-derived
growth factor receptor alpha (
PDGFRA) exon 18 mutation,
including PDGFRA D842V mutations.
Avapritinib is also
indicated for the...
- is a
diagnosis of exclusion,
after clonal eosinophilia (such as FIP1L1-
PDGFRA-fusion
induced hypereosinophelia and leukemia) and
reactive eosinophilia...
-
rearrangements in
PDGFRA, PDGFRB, or FGFR1. CEL not
otherwise specified (CEL NOS) is a form in
which BCR-ABL1
fusion genes and
PDGFRA, PDGFRB, and FGFR1...
-
count must be >1x109/L, no
Philadelphia chromosome or
mutations in the
PDGFRA or
PDGFRB gene
should be present, the
blast count must be <20% and dysplasia...
-
proneural subtype often has high
rates of
alterations in TP53 (p53), and in
PDGFRA the gene
encoding a-type platelet-derived
growth factor receptor. The mesenchymal...
