-
interacts with
PDGFR-αα and -αβ, but not with -ββ, and
thereby resembles PDGF-AB. PDGF-DD
binds to
PDGFR-ββ with high affinity, and to
PDGFR-αβ to a markedly...
-
targeting multiple tyrosine kinases such as CSF1R, ABL, c-KIT, FLT3, and
PDGFR-β. Specifically, it is used for
chronic myelogenous leukemia (CML) and acute...
-
receptor for PDGF,
PDGFR is
classified as a
receptor tyrosine kinase (RTK), a type of cell
surface receptor. Two
types of
PDGFRs have been identified:...
- PDGF/
PDGFR signaling loop, and that
cooperation of
autocrine PDGFR signaling with
oncogenic was
required for
survival during EMT.
Autocrine PDGFR signaling...
-
PDGFRB has been
shown to
interact with: CRK,
Caveolin 1, Grb2, NCK1, NCK2,
PDGFR-α, PTPN11, RAS p21
protein activator 1, SHC1 and Sodium-hydrogen antiporter...
-
targets of
nintedanib include platelet-derived
growth factor receptor (
PDGFR) α and β;
fibroblast growth factor receptor (FGFR) 1, 2, and 3; vascular...
-
microarray containing 21
chordomas Platelet-derived
growth factor receptor-beta (
PDGFR-b),
epidermal growth factor receptor (EGFR), KIT (CD117) and HER2 were detected...
- GIST mutations. Consequently, it is
critical to
define the
exact nature of
PDGFR-induced
mutant GIST
tumors in
order to
select appropriate therapy particularly...
-
kinases (RTK) FLT3 (FMS-like
Tyrosine Kinase 3),
PDGFR α (Platelet-Derived
Growth Factor Receptor), and
PDGFR β.
Unlike most RTK inhibitors,
crenolanib is...
- factors. Some
examples include: Platelet-derived
growth factor receptor (
PDGFR)
Epidermal growth factor receptor (EGFR)
Insulin receptor and insulin-like...
