-
interacts with
PDGFR-αα and -αβ, but not with -ββ, and
thereby resembles PDGF-AB. PDGF-DD
binds to
PDGFR-ββ with high affinity, and to
PDGFR-αβ to a markedly...
- PDGF/
PDGFR signaling loop, and that
cooperation of
autocrine PDGFR signaling with
oncogenic was
required for
survival during EMT.
Autocrine PDGFR signaling...
-
result in
constitutive activation. Finally,
growth factors outside of the
PDGFR family (non-PDGFs)
activate PDGFRα indirectly. Non-PDGFs bind to
their own...
-
receptor for PDGF,
PDGFR is
classified as a
receptor tyrosine kinase (RTK), a type of cell
surface receptor. Two
types of
PDGFRs have been identified:...
-
targeting multiple tyrosine kinases such as CSF1R, ABL, c-KIT, FLT3, and
PDGFR-β. Specifically, it is used for
chronic myelogenous leukemia (CML) and acute...
-
targets of
nintedanib include platelet-derived
growth factor receptor (
PDGFR) α and β;
fibroblast growth factor receptor (FGFR) 1, 2, and 3; vascular...
-
PDGFRB has been
shown to
interact with: CRK,
Caveolin 1, Grb2, NCK1, NCK2,
PDGFR-α, PTPN11, RAS p21
protein activator 1, SHC1 and Sodium-hydrogen antiporter...
-
kinases (RTK) FLT3 (FMS-like
Tyrosine Kinase 3),
PDGFR α (Platelet-Derived
Growth Factor Receptor), and
PDGFR β.
Unlike most RTK inhibitors,
crenolanib is...
-
microarray containing 21
chordomas Platelet-derived
growth factor receptor-beta (
PDGFR-b),
epidermal growth factor receptor (EGFR), KIT (CD117) and HER2 were detected...
-
receptors (FGFR) 1, 2, 3 and 4, platelet-derived
growth factor receptor (
PDGFR) alpha, c-Kit, and the RET proto-oncogene. Some of
these proteins play roles...
