-
prenylation of proteins; the mode of
action of
oxysterols in
these effects is
still poorly understood.
Several oxysterols are ****ociated with age-related diseases...
-
cellular lipid metabolism.
Oxysterol is a
cholesterol metabolite that can be
produced through enzymatic or
radical processes.
Oxysterols, that are the 27-carbon...
-
contain oxysterols (oxidized cholesterol) in
higher amounts than in
fresh milk (up to 30 μg/g,
versus trace amounts in
fresh milk).
Oxysterols are derivatives...
- EBI2 is a
receptor for
oxysterols. The most
potent activator is 7α,25-dihydroxycholesterol (7α,25-OHC), with
other oxysterols exhibiting varying affinities...
-
interest in
oxysterols arose when they were
shown to
exert inhibitory actions on
cholesterol biosynthesis. This
finding became known as the "
oxysterol hypothesis"...
- However, Fred
Kummerow claims that it is not
dietary cholesterol, but
oxysterols, or
oxidized cholesterols, from
fried foods and smoking, that are the...
- molecules.
These include bile
acids (important in
processing dietary fats),
oxysterols,
neurosteroids (involved in
neurotransmission and excitation), glucocorticoids...
-
suggests that PTCH
regulates SMO by
removing oxysterols from SMO. PTCH acts like a
sterol pump and
removes oxysterols that have been
created by 7-dehydrocholesterol...
-
Daszynski DM,
Santhoshkumar P,
Phadte AS, et al. (June 2019). "Failure of
oxysterols such as
lanosterol to
restore lens
clarity from cataracts". Scientific...
- Rammohan, J.; Schlesinger, P. H.; Covey, D. F.; Rohatgi, R. (2012). "
Oxysterols are
allosteric activators of the
oncoprotein Smoothened".
Nature Chemical...
