- 8-
Oxoguanine (8-hydroxyguanine, 8-oxo-Gua, or OH8Gua) is one of the most
common DNA
lesions resulting from
reactive oxygen species modifying guanine, and...
- 8-
Oxoguanine glycosylase, also
known as OGG1, is a DNA
glycosylase enzyme that, in humans, is
encoded by the OGG1 gene. It is
involved in base excision...
- 8-
oxoguanine, a
major oxidative damage with high
mutagenic potential. Upon
chromosome duplication by
replicative polymerases,
unrepaired 8-
oxoguanine tends...
-
common damage in
mtDNA that is
repaired by base
excision repair is 8-
oxoguanine produced by
oxidation of guanine. Double-strand
breaks can be repaired...
- 8-
oxoguanine deaminase (EC 3.5.4.32, 8-OGD) is an
enzyme with
systematic name 8-
oxoguanine aminohydrolase. This
enzyme catalyses the
following chemical...
-
oxidative DNA
damage 8-
oxoguanine triggers a
switch to
translesion synthesis by DNA
polymerase eta. This
polymerase replicates 8-
oxoguanine with an accuracy...
-
mutations in the DNA. For example,
incorporation of
adenine across from 8-
oxoguanine (right)
during DNA
replication causes a G:C base pair to be
mutated to...
- single-strand breaks,
oxidized pyrimidines and the
oxidized purine 8-
oxoguanine (a
mutagenic DNA change) at 1/10, 1/10, and 1/3rd the
frequencies of UVA-induced...
-
During DNA
replication in the germ line of mice, the
oxidized base 8-
oxoguanine (8-oxoG)
causes spontaneous and
heritable G to T
transversion mutations...
- 8-oxo-dGTP
diphosphatase (EC 3.6.1.55, MutT, 7,8-dihydro-8-
oxoguanine triphosphatase, 8-oxo-dGTPase, 7,8-dihydro-8-oxo-dGTP pyrophosphohydrolase) is an...
