-
Lanosterol synthase (EC 5.4.99.7) is an
oxidosqualene cyclase (OSC)
enzyme that
converts (S)-2,3-
oxidosqualene to a
protosterol cation and
finally to lanosterol...
- (S)-2,3-
Oxidosqualene ((S)-2,3-epoxysqualene) is an
intermediate in the
synthesis of the cell
membrane sterol precursors lanosterol and cycloartenol,...
-
Oxidosqualene cyclases (OSC) are
enzymes involved in
cyclization reactions of 2,3-
oxidosqualene to form
sterols or triterpenes.
There are two
major groups...
- two key enzymes:
squalene monooxygenase and
oxidosqualene cyclase.
Phylogenetic analyses of
oxidosqualene cyclase (Osc)
suggest that some
bacterial Osc...
- Sharpless, Karl
Barry (1968).
Studies of the
mechanism of
action of 2,3-
oxidosqualene-lanosterol cyclase:
featuring enzymic cyclization of
modified squalene...
- β-amyrin
synthase (EC 5.4.99.39, 2,3-
oxidosqualene beta-amyrin cyclase, AsbAS1, BPY, EtAS, GgbAS1, LjAMY1, MtAMY1, PNY, BgbAS) is an
enzyme with systematic...
-
squalene epoxidase a
flavoprotein to
yield (2S)-2,3-
oxidosqualene. In the
second step if the
oxidosqualene is
folded in the
chair conformation in the enzyme...
- monooxygenase) of one of its
terminal double bonds,
resulting in 2,3-
oxidosqualene. It then
undergoes an enzyme-catalysed
cyclisation to
produce lanosterol...
-
enzyme that uses
NADPH and
diatomic oxygen to
oxidize squalene to 2,3-
oxidosqualene (squalene epoxide).
Squalene epoxidase catalyzes the
first oxygenation...
- (S)-2,3-epoxysqualene, and one product, cycloartenol. This
enzyme is an
oxidosqualene cyclase and
belongs to the
family of isomerases,
specifically those...
