-
Oxidosqualene cyclases (OSC) are
enzymes involved in
cyclization reactions of 2,3-
oxidosqualene to form
sterols or triterpenes.
There are two
major groups...
- (S)-2,3-
Oxidosqualene ((S)-2,3-epoxysqualene) is an
intermediate in the
synthesis of the cell
membrane sterol precursors lanosterol and cycloartenol,...
- Sharpless, Karl
Barry (1968).
Studies of the
mechanism of
action of 2,3-
oxidosqualene-lanosterol cyclase:
featuring enzymic cyclization of
modified squalene...
- β-amyrin
synthase (EC 5.4.99.39, 2,3-
oxidosqualene beta-amyrin cyclase, AsbAS1, BPY, EtAS, GgbAS1, LjAMY1, MtAMY1, PNY, BgbAS) is an
enzyme with systematic...
- In
other eukaryotes, the
cyclization product of
epoxidized squalene (
oxidosqualene) is cycloartenol. The
mevalonate pathway (also
called HMG-CoA reductase...
-
Lanosterol synthase (EC 5.4.99.7) is an
oxidosqualene cyclase (OSC)
enzyme that
converts (S)-2,3-
oxidosqualene to a
protosterol cation and
finally to lanosterol...
- squalene, a triterpene. Squalene,
through a
cyclization reaction with 2,3-
oxidosqualene 6 as an
intermediate forms cycloartenol. The
double bond of cycloartenol...
-
synthesis remains unclear: 2,3-
oxidosqualene is
believed to
first be
converted into 2,3,22,23-dioxidosqualene. An
unknown oxidosqualene cyclase produces 3-epicabraleadiol...
- α-Amyrin
synthase (EC 5.4.99.40, 2,3-
oxidosqualene alpha-amyrin cyclase,
mixed amyrin synthase) is an
enzyme with
systematic name (3S)-2,3-epoxy-2,3-dihydrosqualene...
-
squalene epoxidase a
flavoprotein to
yield (2S)-2,3-
oxidosqualene. In the
second step if the
oxidosqualene is
folded in the
chair conformation in the enzyme...
