- An
osteoclast (from
Ancient Gr**** ὀστέον (osteon) 'bone' and κλαστός (clastos) 'broken') is a type of bone cell that
breaks down bone tissue. This function...
-
resorption is
resorption of bone tissue, that is, the
process by
which osteoclasts break down the
tissue in
bones and
release the minerals,
resulting in...
-
Increased osteoclast activity stimulated by
RANKL is a key
mediator of bone
destruction in
metastatic bone disease. This
leads to a
reduction in
osteoclast numbers...
-
these genes can lead to
abnormal osteoclasts(termed
osteoclast-rich osteopetrosis), or
having too few
osteoclasts(
osteoclast-poor osteopetrosis). If this...
- activation-induced
cytokine (TRANCE),
osteoprotegerin ligand (OPGL), and
osteoclast differentiation factor (ODF), is a
protein that in
humans is
encoded by...
- body.
Osteoclasts are
frequently classified and
discussed separately from
other MGCs
which are more
closely linked with disease. Non-
osteoclast MGCs can...
-
osteocytes are
involved in the
formation and
mineralisation of bone;
osteoclasts are
involved in the
resorption of bone tissue.
Modified (flattened) osteoblasts...
- understood. It is
postulated that
osteoclasts are the
cells responsible for the
resorption of the root surface.
Osteoclasts can
break down bone, cartilage...
- more
differentiated myeloid cell
types such as monocytes, macrophages,
osteoclasts,
myeloid dendritic cells, microglia, and
Paneth cells. CSF1R expression...
-
during the
differentiation of
osteoclast precursor cells into
mature osteoclasts,
known as osteoclastogenesis.
Mature osteoclasts then bind to bone through...
