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Levomethorphan Levorphanol Lexanopadol MCOPPB MT-7716 NNC 63-0532
Nociceptin (
orphanin FQ)
Nociceptin (1-11)
Nociceptin (1-13)NH2
Norbuprenorphine Racemethorphan...
-
nociceptin opioid peptide receptor (NOP), also
known as the nociceptin/
orphanin FQ (N/OFQ)
receptor or kappa-type 3
opioid receptor, is a
protein that...
- Nociceptin/
orphanin FQ (N/OFQ), a 17-amino acid neuropeptide, is the
endogenous ligand for the
nociceptin receptor (NOP, ORL-1).
Nociceptin acts as a potent...
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hyperalgesia induced by
intracerebroventricular administration of
nociceptin (
orphanin FQ), as well as the
stimulation of
dopamine release in the striatum, which...
- et al. (June 2014). "Cebranopadol: a
novel potent analgesic nociceptin/
orphanin FQ
peptide and
opioid receptor agonist". The
Journal of
Pharmacology and...
-
kappa receptors),
endorphins (mu receptors), endomorphins, and nociceptin-
orphanin FQ. The
opioid receptors are ~40%
identical to
somatostatin receptors (SSTRs)...
- "Opioid
activity profiles indicate similarities between the nociceptin/
orphanin FQ and
opioid receptors".
European Journal of Pharmacology. 389 (2–3):...
- T,
Matsumura S, et al. (February 2006). "The
opioid peptide nociceptin/
orphanin FQ
mediates prostaglandin E2-induced allodynia,
tactile pain ****ociated...
- (December 2009). "Nociceptin/
orphanin FQ
receptor activation attenuates antinociception induced by
mixed nociceptin/
orphanin FQ/mu-opioid
receptor agonists"...
-
nanomolar affinity (Ki) and
efficacy (EC50) at
human recombinant nociceptin/
orphanin-FQ
peptide (NOP) receptors. It has a high
degree of
functional selectivity...
