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Orotic acid (/ɔːˈrɒtɪk/) is a
pyrimidinedione and a
carboxylic acid. Historically, it was
believed to be part of the
vitamin B
complex and was
called vitamin...
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Orotic aciduria (AKA
hereditary orotic aciduria) is a
disease caused by an
enzyme deficiency,
resulting in a
decreased ability to
synthesize pyrimidines...
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Orotate phosphoribosyltransferase (OPRTase) or
orotic acid
phosphoribosyltransferase is an
enzyme involved in
pyrimidine biosynthesis. It
catalyzes the...
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Magnesium orotate, the
magnesium salt of
orotic acid, is a
mineral supplement. It can be used in
treating extracellular magnesium deficiency, as well as...
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Lithium orotate (C5H3LiN2O4) is a salt of
orotic acid and lithium. It is
available as the monohydrate, LiC5H3N2O4·H2O. In this compound,
lithium is non-covalently...
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enzyme block is
proximal to
these intermediates) and
increased orotic acid. The
increased orotic acid
concentrations result from the
buildup of
carbamoyl phosphate...
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carried out by the
protein UMP synthase.
Defective UMP
synthase can
result in
orotic aciduria, a
metabolic disorder. In a study,
gerbils fed a
combination of...
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pyrimidine synthesis can lead to the
genetic disease Orotic aciduria which causes excessive excretion of
orotic acid in the urine.
Nucleotides are
initially made...
- carbamoyl-phosphate in the
cytoplasm to the
common precursor ring
structure orotic acid, onto
which a
phosphorylated ribosyl unit is
covalently linked. Purines...
- pattern. OTC
deficiency is also
accompanied by
hyperammonemia and high
orotic acid levels. BUN is
usually reported in mg/dL in some
countries (e.g. United...
