-
Orexin (/ɒˈrɛksɪn/), also
known as hypocretin, is a
neuropeptide that
regulates arousal, wakefulness, and appetite. It
exists in the
forms of
orexin-A...
- gene (HCRTR1, HCRTR2). Both
orexin receptors exhibit a
similar pharmacology – the 2
orexin peptides,
orexin-A and
orexin-B, bind to both
receptors and...
- An
orexin receptor antagonist, or
orexin antagonist, is a drug that
inhibits the
effect of
orexin by
acting as a
receptor antagonist of one (selective...
-
Orexin-A, also
known as hypocretin-1, is a
naturally occurring neuropeptide and
orexin isoform. The
orexinergic nucleus in the
lateral hypothalamus is...
-
clinically characterized by
symptoms of EDS and cataplexy, and/or will have CSF
orexin levels of less than 110 pg/ml.
Cataplexy are
transient episodes of aberrant...
- (e.g., anandamide) and the
orexin neuropeptides orexin-A and
orexin-B are the
primary signaling neurochemicals in
orexin neurons; pathway-specific neurochemicals...
- Suvorexant, sold
under the
brand name Belsomra, is an
orexin antagonist medication which is used in the
treatment of insomnia. It is
indicated specifically...
-
colocalized on
orexin projection neurons in the
lateral hypothalamus and many
output structures of the
orexin system,
where the CB1 and
orexin receptor 1...
- Daridorexant, sold
under the
brand name Quviviq, is an
orexin antagonist medication which is used for the
treatment of insomnia.
Daridorexant is taken...
-
Orexin receptor type 1 (Ox1R or OX1), also
known as
hypocretin receptor type 1 (HcrtR1), is a
protein that in
humans is
encoded by the HCRTR1 gene. The...
