- via
mitochondrial metabolism.
Oncometabolite production is
another example of
metabolic deregulation.
Oncometabolites are
metabolites whose abundance...
-
which serve to
facilitate tumorigenesis,
dubbed oncometabolites.
Among the best
characterized oncometabolites is 2-hydroxyglutarate
which is
produced through...
- alpha-ketoglutarate or the GABA shunt.[citation needed]
Succinate is one of
three oncometabolites,
metabolic intermediates whose ac****ulation
causes metabolic and non-metabolic...
-
metabolic enzymes IDH1 and IDH2,
which lead to the
generation of a
novel oncometabolite, D-2-hydroxyglutarate,
which inhibits the
activity of
epigenetic enzymes...
- dehydrogenase-1
inhibitor that
works by
decreasing abnormal production of the
oncometabolite 2-hydroxyglutarate (2-HG),
leading to
differentiation of
malignant cells...
- (2018-01-17). "Metabolic
Alterations in
Cancer Cells and the
Emerging Role of
Oncometabolites as
Drivers of
Neoplastic Change". Antioxidants. 7 (1): 16. doi:10.3390/antiox7010016...
- Tian YM,
Hillringhaus L, Bagg EA, Rose NR, et al. (May 2011). "The
oncometabolite 2-hydroxyglutarate
inhibits histone lysine demethylases". EMBO Reports...
-
involvement of
particular enzymes such as PKM2,
mutated IDH as well as
novel oncometabolites such as 2-hydroxyglutarate in
cancer development have once
again brought...
-
dysfunctional in the
citric acid cycle, it can lead to a
buildup of the
oncometabolite succinate,
which can lead to tumorogenesis. This is well-known to occur...
- NIT2/omega-amidase may be
useful for
detection and
conversion of
oncometabolites.
Because omega-amidase is able to
control concentration of
toxic substrates...
