- via
mitochondrial metabolism.
Oncometabolite production is
another example of
metabolic deregulation.
Oncometabolites are
metabolites whose abundance...
- alpha-ketoglutarate or the GABA shunt.[citation needed]
Succinate is one of
three oncometabolites,
metabolic intermediates whose ac****ulation
causes metabolic and non-metabolic...
-
which serve to
facilitate tumorigenesis,
dubbed oncometabolites.
Among the best
characterized oncometabolites is 2-hydroxyglutarate
which is
produced through...
- (2018-01-17). "Metabolic
Alterations in
Cancer Cells and the
Emerging Role of
Oncometabolites as
Drivers of
Neoplastic Change". Antioxidants. 7 (1): 16. doi:10.3390/antiox7010016...
- dehydrogenase-1
inhibitor that
works by
decreasing abnormal production of the
oncometabolite 2-hydroxyglutarate (2-HG),
leading to
differentiation of
malignant cells...
-
metabolic enzymes IDH1 and IDH2,
which lead to the
generation of a
novel oncometabolite, D-2-hydroxyglutarate,
which inhibits the
activity of
epigenetic enzymes...
- Tian YM,
Hillringhaus L, Bagg EA, Rose NR, et al. (May 2011). "The
oncometabolite 2-hydroxyglutarate
inhibits histone lysine demethylases". EMBO Reports...
-
dysfunctional in the
citric acid cycle, it can lead to a
buildup of the
oncometabolite succinate,
which can lead to tumorogenesis. This is well-known to occur...
-
altered enzyme converts α-KG into D-2-hydroxyglutarate (D-2HG), an
oncometabolite.
Elevated D-2HG
levels disrupt normal cellular processes by inhibiting...
-
seizures in
childhood epilepsy 2-Hydroxyglutarate (2HG): 71–72 1.90
Oncometabolite (cancer-causing) Part of
butanoate metabolic pathway None
Elevated levels...
