- metabolites, and lead to tumorigenesis.
These metabolites are
known as
oncometabolites, and can act as biomarkers. In the 1920s, Otto
Heinrich Warburg discovered...
-
dysfunctional in the
citric acid cycle, it can lead to a
buildup of the
oncometabolite succinate,
which can lead to tumorogenesis. This is well-known to occur...
- dehydrogenase-1
inhibitor that
works by
decreasing abnormal production of the
oncometabolite 2-hydroxyglutarate (2-HG),
leading to
differentiation of
malignant cells...
-
which serve to
facilitate tumorigenesis,
dubbed oncometabolites.
Among the best
characterized oncometabolites is 2-hydroxyglutarate
which is
produced through...
- (2018-01-17). "Metabolic
Alterations in
Cancer Cells and the
Emerging Role of
Oncometabolites as
Drivers of
Neoplastic Change". Antioxidants. 7 (1): 16. doi:10.3390/antiox7010016...
- alpha-ketoglutarate or the GABA shunt.[citation needed]
Succinate is one of
three oncometabolites,
metabolic intermediates whose ac****ulation
causes metabolic and non-metabolic...
-
metabolic enzymes IDH1 and IDH2,
which lead to the
generation of a
novel oncometabolite, D-2-hydroxyglutarate,
which inhibits the
activity of
epigenetic enzymes...
- Tian YM,
Hillringhaus L, Bagg EA, Rose NR, et al. (May 2011). "The
oncometabolite 2-hydroxyglutarate
inhibits histone lysine demethylases". EMBO Reports...
-
Claridge TD,
Ratcliffe PJ,
Schofield CJ,
Kawamura A (May 2011). "The
oncometabolite 2-hydroxyglutarate
inhibits histone lysine demethylases". EMBO Rep....
- Wang P, Kim SH, Ito S, Yang C, Wang P, Xiao MT, Liu Lx (2011-01-18). "
Oncometabolite 2-Hydroxyglutarate Is a
Competitive Inhibitor of α-Ketoglutarate-Dependent...
