- An
oncogene is a gene that has the
potential to
cause cancer. In
tumor cells,
these genes are
often mutated, or
expressed at high levels. Most
normal cells...
-
Oncogene is a peer-reviewed
scientific journal published under the
Springer Nature addressing cancer cell
genetics and the
structure and
function of oncogenes...
-
Oncogene addiction is a
process in
which cancers with genetic, epigenetic, or
chromosomal irregularities become dependent on one or
several genes for maintenance...
- into the host cell or to
enhance already existing oncogenic genes (proto-
oncogenes) in the genome. For example, it has been
shown that
vFLIP and vCyclin...
- A
tumor suppressor gene (TSG), or anti-
oncogene, is a gene that
regulates a cell
during cell
division and replication. If the cell
grows uncontrollably...
- The RET proto-
oncogene encodes a
receptor tyrosine kinase for
members of the
glial cell line-derived
neurotrophic factor (GDNF)
family of extracellular...
-
produce a
functional fusion protein. Many
important cancer-promoting
oncogenes are
fusion genes produced in this way.
Examples include: Gag-onc fusion...
-
Transcription factor Maf, also
known as proto-
oncogene c-Maf or V-maf
musculoaponeurotic fibrosarcoma oncogene homolog, is a
transcription factor that in...
-
positive regulator of cell migration. Akt1 was
originally identified as the
oncogene in the
transforming retrovirus, AKT8. Akt2 is an
important signaling molecule...
-
three Ras
genes in
humans (HRAS, KRAS, and NRAS) are the most
common oncogenes in
human cancer;
mutations that
permanently activate Ras are
found in...
