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Obeticholic acid (OCA), sold
under the
brand name Ocaliva, is a semi-synthetic bile acid
analogue which has the
chemical structure 6α-ethyl-chenodeoxycholic...
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intestinal disorder, bile acid diarrhea. The company's lead
product is
obeticholic acid, OCA, also
known as 6-ethyl-chenodeoxycholic acid or INT-747, marketed...
-
randomized clinical trials to be effective. The
farnesoid X
receptor agonist obeticholic acid has
shown clinical and
biochemical benefits in a
proof of concept...
- is
expected in 2/3 of
patients on UDCA. For the 1/3 non-responders,
obeticholic acid (OCA) is
approved by the FDA as a second-line treatment. The precise...
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chenodeoxycholic acid but with the 7-hydroxyl
group in the β position.
Obeticholic acid, 6α-ethyl-chenodeoxycholic acid, is a semi-synthetic bile acid with...
- the rate of
liver transplantation,
pruritus or fatigue.
Ursodiol and
obeticholic acid are FDA-approved for the
treatment of
primary biliary cholangitis...
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Chenodeoxycholic acid
Cilofexor Fexaramine GW-4064
Ivermectin Nidufexor Obeticholic acid
Tropifexor Antagonists:
Guggulsterone LXRTooltip Liver X receptor...
- UDCA has been the only drug
available for two
decades and more
recently obeticholic acid (OCA), a semi-synthetic
hydrophobic bile acid analogue, has been...
- the
treatment and
prevention of
malaria Bile acid
congeners such as
obeticholic acid
Gestational pemphigoid, a
dermatosis of
pregnancy Intrahepatic cholestasis...
-
trials are
underway that aim to slow
progression of this
liver disease.
Obeticholic acid is
being investigated as a
possible treatment for PSC due to its...
