- out the
complex molecular mechanisms that
regulate activity of caspase-8,
OTULIN, RIPK1, RIPK3 and
other proteins that
modulate inflammation,
apoptosis and...
- NF-κB signaling. Also the
hypomorphic mutations in
deubiquitinase enzyme OTULIN (from OTU
deubiquitinase with
linear linkage specificity),
results in elevated...
-
OTULIN Identifiers Aliases OTULIN, FAM105B, GUM, OTU
deubiquitinase with
linear linkage specificity,
AIPDS External IDs OMIM: 615712; MGI: 3577015; HomoloGene:...
-
Complex I is
negatively regulated by
deubiquitinases such as A20, CYLD, and
OTULIN,
which destabilize complex I.
Complex II is
formed when RIPK1 and/or TRADD...
- inflammasome,.
Antagonistic to
LUBAC are
deubiquitinases such as
OTULIN or CYLD, of
which OTULIN is the only
deubiquitinase that
removes M1-linked ubiquitin...
- Q8N6M0 11565 OTUD7A HGNC:20718 Q8TE49 11566 OTUD7B HGNC:16683 Q6GQQ9 11567
OTULIN HGNC:25118 Q96BN8 11568
OTULINL HGNC:25629 Q9NUU6 11569 OTX1 HGNC:8521 P32242...
- PMID 31101826. Lork M,
Verhelst K,
Beyaert R (July 2017). "CYLD, A20 and
OTULIN deubiquitinases in NF-κB
signaling and cell death: so similar, yet so different"...
-
Akutsu M, Olma MH,
Gomes LC,
Kawasaki M,
Dikic I (May 2014). "Binding of
OTULIN to the PUB
domain of HOIP
controls NF-κB signaling".
Molecular Cell. 54...
-
Akutsu M, Olma MH,
Gomes LC,
Kawasaki M,
Dikic I (May 2014). "Binding of
OTULIN to the PUB
domain of HOIP
controls NF-κB signaling".
Molecular Cell. 54...
- PMID 32783365. Lork M,
Verhelst K,
Beyaert R (July 2017). "CYLD, A20 and
OTULIN deubiquitinases in NF-κB
signaling and cell death: so similar, yet so different"...
