Definition of Nutlin. Meaning of Nutlin. Synonyms of Nutlin

- chemical library by V****ilev et al. Nutlin-1, nutlin-2, and nutlin-3 were all identified in the same screen; however, Nutlin-3 is the compound most commonly...
- Success stories include the MDM2 motif analog Nutlin-3 and integrin targeting RGD-mimetic Cilengitide: Nutlin-3 antagonises the interaction of MDM2's SWIB...
- Neganova I, Armstrong L, et al. (September 2008). "Activation of p53 by nutlin leads to rapid differentiation of human embryonic stem cells". Oncogene...
- inhibition of human tumor xenografts in nude mice. The most active compounds are nutlin-3a and rg-7112, but some other analogs also activate p53. Surfactants based...
- idea that activation of p53 is an appealing strategy for cancer treatment. Nutlin-3 is a small molecule designed to target p53 and Mdm2 interaction that kept...
- Inhibitors of the MDM2-p53 interaction include the cis-imidazoline analog nutlin. Levels and stability of Mdm2 are also modulated by ubiquitylation. Mdm2...
- activity and its antitumour effects. Drugs that utilize this mechanism include nutlin and MI-219, which are both in phase I clinical trials. As of 2009[update]...
- in cancer therapy is Nutlin. Nutlin inhibits the interaction between HDM2 and tumour suppressor p53. After the discovery of Nutlin, more than 20 small...
- UV irradiation, based on precisely timed additions of the Mdm2 inhibitor Nutlin-3. Cells damaged using gamma irradiation without drug treatment showed cell...