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Nucleophosmin (NPM), also
known as
nucleolar phosphoprotein B23 or numatrin, is a
protein that in
humans is
encoded by the NPM1 gene. In humans, the NPM1...
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which is
important in rRNA processing. The GC
contains the
protein nucleophosmin, (B23 in the
external image),
which is also
involved in
ribosome biogenesis...
- the
kinase domain of ALK is
fused to the amino-terminal part of the
nucleophosmin (NPM) protein.
Dimerization of NPM
constitutively activates the ALK...
- be
performed to look for
specific mutations in
genes such as FLT3,
nucleophosmin, and KIT,
which may
influence the
outcome of the disease. Cytochemical...
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bordered by the
granular component (GC) (that
contains the
protein nucleophosmin).
Transcription of the rDNA
occurs either in the FC or at the FC-DFC...
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responsible for
regulation of
centriole duplication:
nucleophosmin (NPM/B23), CP110, and MPS1.
Nucleophosmin is only
found in
unreplicated centrosomes and its...
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described in APL
fusing RARA to
promyelocytic leukemia zinc
finger (PLZF),
nucleophosmin,
nuclear matrix ****ociated,
signal transducer and
activator of transcription...
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related to the
nuclear chaperone phosphoproteins,
nucleoplasmin and
nucleophosmin. It is
highly homologous to the
murine Npm3 gene.
Based on the structural...
- NPM1-ALK
fusion protein. It is made by a
fusion of NPM1 gene,
which makes nucleophosmin 1,
located on the long or "q" arm of
chromosome 5 at
position 35 (notated...
-
requires ATP.
Humans express three members of the
nucleoplasmin family:
Nucleophosmin (NPM1)
Nucleoplasmin 2 (NPM2)
Nucleoplasmin 3 (NPM3)
Dingwall C, Laskey...
